DARPA’s new Synthetic Hemo-technologIEs that Locate & Disinfect (SHIELD) program aims to develop broad, preventive treatments for warfighters who suffer trauma from gunshot or blast wounds, or burns. Novel therapies would be administered as combat casualty care post-trauma with the aim to bind, clear, and defeat any fungi and bacteria in a pathogen-agnostic, or broad-spectrum manner before they can become a health risk. These therapies will be designed to protect the recipient for up to a week with a single dose; be durable, non-toxic, rapidly and broadly deployable; and be effective against the many different known and emerging bacterial and fungal threats.